Feverfew compound gets at leukemia roots

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Feverfew compound gets at leukemia roots

Wednesday, February 23, 2005A compound in the common daisy-like plant feverfew kills human leukemia stem cells and could form the basis for newer, more effective drugs for the disease.

American researchers at the University of Rochester Medical Center in New York say that it could take months to develop a useable drug from the compound, parthenolide.

However, they are working to do so with chemists at the University of Kentucky who have identified a water-soluble molecule with the same properties. The US National Cancer Institute has also accepted the work into its rapid access program, which aims to speed experimental drugs into human clinical trials.

“This research is a very important step in setting the stage for future development of a new therapy for leukemia,” says Rochester researcher Craig Jordan. “We have proof that we can kill leukemia stem cells with this type of agent, and that is good news.”

Parthenolide appears to target the roots of myeloid leukemia, stem cells, while current treatments including the relatively new drug Gleevec don’t. So, “You’re pulling the weed without getting to the root,” says Jordan.

Used for centuries to fight fevers, inflammation and arthritis, feverfew earned interest from the Rochester researchers after other scientists showed that it could prevent skin cancer in animal models.

So the researchers investigated how a concentrated form of the plant component parthenolide would affect leukemia cells and normal cells.

Comparing the impact of parthenolide to the common chemotherapy drug cytarabine, they found that parthenolide selectively killed leukemia cells while sparing normal cells better.

While the findings suggest that parthenolide is a good starting point for new drugs, people with leukemia aren’t being encouraged to take high doses of feverfew as they could not take enough of the remedy to halt the disease.

The research is reported in the journal Blood.

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Home Cooling Systems For The Diy Expert

By Chickie Maxwell

Heating and cooling a house is a concern for all homeowners, especially for those people that pride themselves on being do-it-yourselfers. Which cooling systems are the most effective while offering a low energy cost over the life of the unit? Luckily, technology has provided a number of different system types to keep everyone warm and cool as the seasons change.

One basic way to cool a home is to use ventilation techniques through strategic fan placement. Homes can be outfitted with rooftop fan ventilators that will pull heated air from the top of the home, like in the attic, so that it escapes into the atmosphere. The air that replaces the escaped heated air within the space will generally be cooler. Other cooling systems include permanently installed ceiling fans and removable window fans. These are commonly operated in spaces that have a lot of use, like living rooms and bedrooms. Alternatively, some DIYers take advantage of a home’s duct system; a fan system can be installed to move air throughout a home that has ducts entering each main room area. Regardless of the fan ventilation choice, the main benefit to this home cooling system is its inexpensive operation over the years; it only takes a minimal amount of electricity to run the fans.

Homeowners may also use the same ducts for heating that they use for cooling systems. A boiler or furnace can be attached to this duct system to provide warm air during the colder months. As a result, the entire home is kept at a comfortable temperature while retaining a low energy bill at the end of the month.

[youtube]http://www.youtube.com/watch?v=-AtsiPDGp4I[/youtube]

These same ducts for fans and heat systems can also be equipped with an air conditioning system. These cooling systems are highly effective for cooling a home, especially if the outside temperatures are extremely dry and hot. However, a DIYer should note that the air conditioning installation can be relatively difficult, along with increasing the home’s electrical bill.

Alternatively, some homeowners in dry climates use evaporative coolers as another inexpensive strategy for cooling a house. Much like air conditioners, the cooler chills hot, incoming air. But, the cooler adds moisture to the incoming hot air to cool it off. This use of evaporation cools the interior of the home while hot air escapes through a cracked window. These coolers are also referred to as swamp coolers.

Some DIY homeowners install radiant heating and cooling systems within their floors for warming and cooling the building. As suggested by the name, radiant heating sends out warmth from its installed piping within the floor; many installations use hot water flows from a heated boiler to warm the home’s interior. Alternatively, radiant cooling helps retain a comfortable temperature within the home during the warm months. Operating in the opposite direction, radiant cooling absorbs heat through the floor and into the piping to pull hot air from a specific area.

Every DIY homeowner should research the best heating and cooling system for the particular climate the home resides within. Each system has its benefits and drawbacks, based on the humidity or dryness of a region.

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Wikinews interviews Joe Schriner, Independent U.S. presidential candidate

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Wikinews interviews Joe Schriner, Independent U.S. presidential candidate

Saturday, April 17, 2010

Journalist, counselor, painter, and US 2012 Presidential candidate Joe Schriner of Cleveland, Ohio took some time to discuss his campaign with Wikinews in an interview.

Schriner previously ran for president in 2000, 2004, and 2008, but failed to gain much traction in the races. He announced his candidacy for the 2012 race immediately following the 2008 election. Schriner refers to himself as the “Average Joe” candidate, and advocates a pro-life and pro-environmentalist platform. He has been the subject of numerous newspaper articles, and has published public policy papers exploring solutions to American issues.

Wikinews reporter William Saturn? talks with Schriner and discusses his campaign.

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Former Indonesian president, Suharto in critical condition

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Former Indonesian president, Suharto in critical condition

Saturday, January 5, 2008

Former Indonesian President Suharto, 86, is in a Jakarta hospital in critical condition. Doctors say he is suffering heart problems. Chad Bouchard reports from Jakarta.

The former president was admitted to a hospital on Friday with swelling throughout his body. Doctors say Mr. Suharto’s heart has become too weak to pump blood properly, and his kidneys are deteriorating.

Andi Mallarangeng, spokesman for current president Susilo Bambang Yudhoyono, says the president visited Mr. Suharto in the hospital Saturday and found him too weak to talk.

He was conscious, he was not in a coma in that sense, he was conscious, but he was very weak

“He was conscious, he was not in a coma in that sense, he was conscious, but he was very weak,” he said. “The presidential doctors informed the president that President Suharto is in [a] critical situation.”

Suharto ruled Indonesia for 32 years, stepping down after widespread demonstrations and rioting during the Asian economic crisis of 1998.

He has since lived quietly in an upscale district of central Jakarta.

The anti-corruption organization Transparency International says Mr. Suharto embezzled more from Indonesia than any other modern leader, an estimated $15 billion to $35 billion. Mr. Suharto has steadfastly denied such accusations.

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Toothpaste fills cavities without drilling

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Toothpaste fills cavities without drilling
October 8th, 2020 in Uncategorized | No Comments

Thursday, February 24, 2005

A paste containing synthetic tooth enamel can seal small cavities without drilling. Kazue Yamagishi and colleagues at the FAP Dental Institute in Tokyo say that the paste can repair small cavities in 15 minutes.

Currently, fillers don’t stick to such small cavities so dentists must drill bigger holes. Hydroxyapatite crystals, of which natural enamel is made, bond with teeth to repair tiny areas of damage.

Yamagishi and colleagues have tested their paste on a lower premolar tooth that showed early signs of decay. They found that the synthetic enamel merged with the natural enamel. The synthetic enamel also appears to make teeth stronger which will improve resistance to future decay. As with drilling, however, there is still the potential for pain: The paste is strongly acidic to encourage crystal growth and causes inflammation if it touches the gums.

The paste is reported in the journal Nature.

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Category:Animal rights

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Category:Animal rights
October 8th, 2020 in Uncategorized | No Comments

This is the category for animal rights.

A tangentially related topic, for which Wikinews also has a category, is animal sacrifice.

Refresh this list to see the latest articles.

  • 11 June 2020: Police arrest twelve after explosives kill jackal in Tamil Nadu, India
  • 7 June 2020: Suspect arrested in death of elephant in Kerala, India that ate explosive fruit
  • 30 April 2020: Neuroscientists tell Wikinews about empathy and harm aversion observed in lab rats
  • 16 May 2019: Actor Doris Day dies at 97
  • 10 March 2015: Sam Simon, ‘The Simpsons’ co-creator, dies aged 59
  • 31 January 2015: Scottish gamekeeper jailed for bird crime in national first
  • 21 March 2013: Anonymous people reveal animal cruelty at Australian Inghams poultry producer factory using CCTV footage
  • 28 April 2012: Florida man accused of threatening to bomb animal shelter
  • 10 October 2010: Animal rights activists demand British coffee chain withdraw advertising campaign
  • 20 September 2010: UK animal welfare group prosecutes woman who threw cat into bin
?Category:Animal rights

From Wikinews, the free news source you can write.


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Pages in category “Animal rights”

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Plywood Boat Plans The World Standard

September 26th, 2020 in Timber | No Comments

By David Web

For a boating lover, every aspect related to boating is very important. It would be very exciting for any boating lover to know about the best plywood boat plans, as then it is possible for him or her to build a unique masterpiece at home themselves. There are several methods available, by which you can prepare several boating accessories at home. Boating was not considered very popular previously, but now the trend is changing and more and more people are opting for boating, as a leisure time activity. The popularity of boating can be seen from the fact that there are large numbers of events organized in order to promote it.

There are several techniques available by which you can prepare your own plywood boat like with the help of some useful reference guides that would enable you to make your own accessories and are sufficient to provide the best boating pleasure. There are 2 techniques, by which you can make the masterpiece by your own. Out of the two methods, we are just going to take the first method here that would assist you in making the best possible masterpiece and that too on your own. As for everything, for this work also there is need of some special attributes like skill, intelligence, creativity etc. In addition, you must have the will to convert your dream into reality as well.

[youtube]http://www.youtube.com/watch?v=DDisMlwlSgk[/youtube]

Among the two methods, we are considering the traditional method where first of all you need to make the plywood plans of all the things you require for making the project. In this method ply on the frame is used. Among other things, it is also very important that you should have the best tools to complete the project. Boating is really a pleasurable activity, but it is not just a measure for fun, rather it is also associated with the lives of several people. For this reason, it is very important not to make any mistakes in constructing the boat. Proper tools as well as materials should be used in order to ensure full safety. After considering the above aspects only, you can think of proceeding with the next step.

Starting with the first method of preparing the ply boat, the first and the foremost thing that is required is best quality wood. Quality of wood is very important because it is with the help of wood only, that you can make the best quality wooden frame that is a must for the whole construction. This wooden frame is popularly known as the ribs. The ribs are positioned in such a way that the hull can be built on the upside down direction with the help of the jig.

After the first phase is over, the next thing is to attach the longitudinal members of the wooden frame with the notch slots that are available in the ribs. The first element used is quite heavy and is known as keelson and it runs to the center down to the ribs. It is on the forward end point of this element only, that the vertical timber is attached. This vertical timber is known as stem and is used in forming the prow for the plywood boat.

About the Author: PART 2 – For part two of this article, head on to

Plywood Boat Plans

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Funding gap forces library closures in Jackson County, Oregon

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Funding gap forces library closures in Jackson County, Oregon
September 22nd, 2020 in Uncategorized | No Comments

Wednesday, February 14, 2007

Due to a US$23 million budget shortfall, all public libraries in Jackson County, Oregon are scheduled to close April 6. The U.S. Congress did not renew the Secure Rural Schools and Self-Determination Act, which replaces property tax revenues with revenue sharing from timber harvests. Jackson County used the revenue to pay for libraries and sherriff’s patrols. Voters rejected a property tax increase last November. A similar increase will appear on the May ballot; such increases must pass a double-majority vote: a majority of county voters must turn out for the election, and a majority of those must support the increase.

Supporters hope the measure will pass this time. “Many people didn’t believe we were going to close libraries.” said County Commissioner C.W. Smith. The Ashland City Council has said it would find a funding solution to keep their branch of the library open; other cities have not made similar statements. Some alternative funding solutions, such as charging subscription fees, have been considered. However, charging fees for access to libraries is illegal in Oregon.

Jackson County is located in Southern Oregon, and has a population of 181,000. The Jackson County Library System consists of 15 branches.

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4 Reasons On Why You Should Get A Life Insurance

September 11th, 2020 in Seniors | No Comments

Submitted by: Insurancesc Leads

We often hear people ask: “Do I need Insurance?” Almost everyone doubts to get one. Why? Because of the fast-spreading scams and frauds that pretend to be a legal insurance company but does nothing but steal your money and swindle your bank accounts. But let’s go back to the topic. Do we really need insurance? The answer is, of course, yes! We need this in almost every aspect of our lives. Whenever we drive a car, we need car insurance. We need insurance to protect both our lives and our family’s. Also, some of our possessions need also to be insured. One of the most important types of insurance is the Life Insurance. There are many reasons why we should get one. I have listed some of the main reasons below.

1st – Life in the world is getting tougher and tougher each day. You begin to worry about almost everything including the food that you’ll eat. Even if death comes upon you, worries will never stop bother your family because even a common burial costs a lot of money. And even if you don’t have a family, you don’t want people to just dump your body in the ocean.

[youtube]http://www.youtube.com/watch?v=-7QGzuY5ye0[/youtube]

2nd – You’re family will never be burdened with financial problems. Expenses such as mortgage payments and vehicle payments, among others, will continue long after you’ve drawn your last breath. Your family will still feel your support even though you’re long gone.

3rd – Because of your parents’ old age, they cannot work anymore to earn money and their pensions are not enough to support their lives. That’s why you struggle and earn a living for them. You provide them with not only the basic needs but also some of the things that we consider luxury. But what if you die today? You do not want seeing your parents struggle in the remaining days of their lives right? Having your parents named as beneficiaries under a life insurance policy could provide them the things that they would need in the future.

4th – You are the one taking care of the education of your children. Because of your desire to let your children achieve their dreams you send them to a good school though it has a very high tuition fee. But what if you can no longer pay the bills of your children’s education because of your death? Being insured in a life insurance not only takes care of your burial and household, it also provides future educational expenses for your children. Therefore, though you do no longer exist, your children are assured upon having the best education that they will need.

Of course these are not only the reasons why you should be insured. There are many more reasons depending upon your status in life and capabilities. His reason may differ from your reason but whatever that is, it is still for your benefit and of course your loved ones too.

About the Author: Prince Vasquez is an Internet Marketer and a writer of various article topics such as

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At least fifteen dead after landslide in Indonesia

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At least fifteen dead after landslide in Indonesia
September 7th, 2020 in Uncategorized | No Comments

Thursday, February 25, 2010

At least fifteen people have been killed as the result of a landslide which occurred in Indonesia on Tuesday. According to BBC News Online, at least sixteen were killed. It is thought that up to seventy people were killed as a result of the landslide, which occurred in a village near to the city of Bandung.

At one point, villagers attempted to dig out surviving victims from the rocks and mud by using their bare hands, as rescue efforts were suspended temporarily due to heavy rain, before recommencing after lifting equipment arrived. At least sixteen dead bodies have been recovered by Wednesday. Roughly five hundred people are contributing to the search and rescue.

Priyadi Kardono, spokesperson for the Disaster Management Agency, stated: “We’ve found fifteen bodies so far and estimate that there are up to 70 people still missing.” He also commented that fifteen other people had been injured, of which two have been hospitalised.

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